There was an argument on another forum regarding towing in fifth with a certain brand of vehicle (not Nissan). Those opposed to the towing in fifth claimed the 'fifth' gear arrangement in the auto trans was weak and could likely break. However there wasn't a single example on the forum where someone had physically broken the fifth gear, output shaft or any other component of the transmission from towing in fifth gear - so the theory didn't appear to match the reality in this case. The vehicle in question has been on the market for over a decade, however sometimes facts don't seem to matter when there are strong opinions involved.
I often towed in fifth gear and never had a problem. However, with my latest vehicle (NW Pajero) I fitted a scangauge plugged into the OBD port that I use to monitor transmission temperatures. What is very obvious is that when driving in fifth gear up long hills, even when not towing, the transmission temperatures can rise very quickly. Not hard to exceed 100C temps without trying, and I'm running two large external transmission coolers as well. Made me wonder how hot my transmission had got in my previous vehicle when towing in 5th for extended periods in hot whether with the car loaded and with the family onboard.
For the longevity of the trans oil, and transmission, everything I've read suggests to try and keep the transmission oil below 100C when possible. Towing in 5th with the Pajero under load (ie, into a head wind, up hills etc) it's impossible to keep the temps below 100C because of the convertor slip. In these circumstance I drop it back to fourth, then back into fifth / drive on the flats and just keep an eye on the temps.
I guess in my experience there isn't an issue with the strength of the gearbox to tow in fifth, and the issue isn't whether the car has enough grunt either. But what I've found is that the transmission temps skyrocket, even when using fully synthetic oils.
Hope this helps.