D4D,
For the Pathfinder, if we're not following anyone and not passing any oncoming traffic, then either one works for us. As soon as there's any dust in the air though, we've got to go to recirc otherwise the cabin fills up. I used to do the "leave it on fresh and turn the fan up high to pressurise the cabin" trick, but found that it easily results in much more dust inside the car. Recirc stops it coming in almost completely.
Our car doesn't come with an in-cabin filter as standard, but I've got the part numbers from the JDM model if I want to install one. I've not done it yet. I suspect a clean cabin filter would help massively once dust did get in. Of course, you'd need to keep cleaning/replacing the filter...
<Opinion with absolutely no supporting evidence offered>
I find it hard to believe that any car is perfectly airtight, especially once it's travelling. You'd never be able to open/close the doors, and if you drove up a mountain you would blow a door out. So I think the likelihood of being able to create dangerously high levels of CO2 inside a car simply from breathing would be amazingly difficult, lest of all time consuming given the volume of air involved. I'm not saying the aforementioned crane doesn't have a 30 minute buzzer for recirc mode, my gut feeling is simply that that is a very conservative time limit, and for a much lower internal volume of air.
Likewise, I doubt the ability of an AC fan or a simple ram-air effect would be sufficient to actually raise the pressure of the air inside the cabin such that it would actually make a difference. Otherwise if you changed your AC from recirc to fresh, you'd feel your ears pop as the pressure rapidly increased.
I suspect the different experience people have is more due to the different cars having their external vent intakes in different positions. IE, if one vehicle sucks air from the base of the windscreen, that's a relatively high-pressure area that has relatively static airflow. If the vent intake is inside the engine bay, it may be in a lower-pressure stream with a high flow-rate that's more susceptible to loading up with dust. My theory is that given these different vent locations, different cars will behave differently on fresh or recirc modes, and owners will have better success on either.
</unwarranted opinion>
Cheers!
Matto